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Vaccination, Transplantation, and a Social Contract
5/11/2022Journal:
J Am Soc Nephrol. 2022 May 11:ASN.2021111501.Authors :
Olivia Kates Ajit Limaye Bruce KaplanNo abstract
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Urinary clearance of 11-nor-9-carboxy-Δ9 -tetrahydrocannabinol: A detailed pharmacokinetic analysis
3/25/2022Journal:
Drug Test Anal. 2022 Mar 24.Authors :
Cristina Sempio Marilyn A Huestis Bruce Kaplan Jost Klawitter Uwe Christians Thomas K HenthornUrine is a common matrix for screening for cannabis use. Urine assays typically measure total 11-nor-9-carboxy-Δ⁹ -tetrahydrocannabinol (THCCOOH) concentrations after hydrolysis cleaves the glucuronide. Urine THCCOOH concentration is adjusted by urine creatinine concentration or specific gravity, to account for variable hydration states. Therefore, we performed a population pharmacokinetic analysis of the urinary THCCOOH excretion, urinary flow rate, and creatinine excretion rate data. Urine was...
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Need for a Validation Study before Using the Two-Step Algorithm for dd-cfDNA to Screen for Acute Rejection
10/30/2021Journal:
J Am Soc Nephrol. 2021 Nov;32(11):2972-2973.Authors :
Aditi Gupta Bruce KaplanNo abstract
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Understanding Risks and Our Responsibility to Living Donors
10/30/2021Journal:
J Am Soc Nephrol. 2021 Nov;32(11):2691-2693.Authors :
John S Gill Jesse Schold Bruce KaplanNo abstract
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VO2peak prior to transplant differentiates survival post kidney transplant
10/22/2021Journal:
Clin Transplant. 2022 Feb;36(2):e14517.Authors :
Harini A Chakkera Bruce Kaplan Pooja Budhiraja Senaida Behmen Dennis Fitz-Patrick Richard J ButterfieldThe OPTN/UNOS utilizes the calculated estimated posttransplant survival (EPTS) score as the measure of post-kidney transplant survival to guide allocation of deceased donor kidney transplantation. This score does not include any metric of functional capacity. Peak oxygen uptake (VO(2peak) ), is an established predictor of survival among both the general and diseased populations. We assessed the association and discriminative capacity of VO(2peak) and that of EPTS score and all-cause mortality...
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High-throughput sequencing defines donor and recipient HLA B-cell epitope frequencies for prospective matching in transplantation
5/15/2021Journal:
Commun Biol. 2021 May 14;4(1):583.Authors :
Jenny N Tran Oliver P Günther Karen R Sherwood Franz Fenninger Lenka L Allan James Lan Ruth Sapir-Pichhadze Rene Duquesnoy Frans Claas Steven G E Marsh W Robert McMaster Paul A Keown Genome Canada Transplant ConsortiumCompatibility for human leukocyte antigen (HLA) genes between transplant donors and recipients improves graft survival but prospective matching is rarely performed due to the vast heterogeneity of this gene complex. To reduce complexity, we have combined next-generation sequencing and in silico mapping to determine transplant population frequencies and matching probabilities of 150 antibody-binding eplets across all 11 classical HLA genes in 2000 ethnically heterogeneous renal patients and...
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Current State of Evidence on Kidney Transplantation: How Fragile Are the Results?
5/9/2021Journal:
Transplantation. 2022 Feb 1;106(2):248-256.Authors :
Pooja Budhiraja Bruce Kaplan Mohamad Kalot Abdallah El Alayli Ahmad Dimassi Harini A Chakkera Raymond Heilman Audrene S Edwards Reem A MustafaCONCLUSIONS: The arbitrary classification of results into "significant" and "nonsignificant" based on P value <0.05 should perhaps be interpreted with the help of other statistical parameters and FI is one of them.
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Transplant administration-A survey of the roles and responsibilities of kidney and pancreas medical directors of US transplant centers
4/2/2021Journal:
Clin Transplant. 2021 Jun;35(6):e14305.Authors :
Neeraj Singh John Friedewald Roy Bloom Darshana Dadhania Ronald F Parsons Bruce Kaplan Millie Samaniego Yasir Qazi Mona Doshi Gwen McNatt Muhammad Saad Naseer Todd Pesavento Alexander WisemanThe current American Society of Transplantation (AST) accredited transplant fellowship programs in the United States provide no structured formal training in leadership and administration which is essential for successfully running a transplant program. We conducted a survey of medical directors of active adult kidney and kidney-pancreas transplant programs in the United States about their demographics, training pathways, and roles and responsibilities. The survey was emailed to 183 medical...
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Personalized physical rehabilitation program and employment in kidney transplant recipients: a randomized trial
3/18/2021Journal:
Transpl Int. 2021 Jun;34(6):1083-1092.Authors :
Alexandra Kastelz Bo Fernhall Edward Wang Ivo Tzvetanov Mario Spaggiari Aneesha Shetty Lorenzo Gallon Greg Hachaj Bruce Kaplan Enrico BenedettiKidney transplantation is the preferred treatment for kidney failure; however after transplant, reduced physical function, poor self-perceptions, and unemployment are common concerns that remain. This randomized controlled trial compared the effects of a 12-month exercise rehabilitation program (intervention) to standard care alone (control) in kidney transplant recipients. The exercise intervention consisted of a 2 day/week, 60-minute personalized, one-on-one, resistance-based exercise...
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Removal of Anti-Thymocyte Globulin by Plasma Exchange in ABO-Incompatible and Positive Crossmatch Kidney Transplant Recipients
2/12/2021Journal:
Transplant Proc. 2021 Jun;53(5):1548-1553.Authors :
Patricia M West-Thielke Heather J Ipema Sally Campbell-Lee Enrico Benedetti Bruce Kaplan James J ThielkeCONCLUSIONS: This is the first study to show that plasma exchange removes a substantial amount of ATG in high-risk kidney transplant patients. Based on these results, we believe these high-risk patients have been traditionally underdosed.
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Improved ability to achieve target trough levels with liquid versus capsule tacrolimus in kidney transplant patients with HIV on protease inhibitor- or cobicistat-based regimens
11/20/2020Journal:
Transpl Infect Dis. 2021 Jun;23(3):e13517.Authors :
Uraiwan Akanit Shahab Bozorgmehri Kawther Alquadan Joelle Nelson Bruce Kaplan Tezcan Ozrazgat-Baslanti Karl L WomerHIV + patients are commonly accepted for kidney transplantation. However, patients on protease inhibitor (PI)- or cobicistat (cobi)-based regimens have trouble achieving optimal tacrolimus (Tac) levels. Our study compared the ability to achieve target levels using liquid versus immediate-release capsule Tac in kidney transplant patients with HIV on PI- or cobi-based regimens. The study included four kidney transplant patients who were converted to liquid Tac due to inability to achieve...
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Reporting and Handling of Missing Participant Data in Systematic Reviews of Kidney Transplant Studies
10/23/2020Journal:
Transplantation. 2021 Aug 1;105(8):1708-1717.Authors :
Pooja Budhiraja Mohamad A Kalot Abdallah El Alayli Ahmad Dimassi Bruce Kaplan Harini A Chakkera Reem A MustafaCONCLUSIONS: Systematic reviews of kidney transplantation provide inadequate information on missing participant data and usually do not handle or discuss the associated risk of bias with it.
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Artificial Intelligence-related Literature in Transplantation: A Practical Guide
8/23/2020Journal:
Transplantation. 2021 Apr 1;105(4):704-708.Authors :
Sook Hyeon Park Nikhilesh R Mazumder Sanjay Mehrotra Bing Ho Bruce Kaplan Daniela P LadnerNo abstract
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A Primer on Machine Learning
8/23/2020Journal:
Transplantation. 2021 Apr 1;105(4):699-703.Authors :
Audrene S Edwards Bruce Kaplan Tun JieNo abstract
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The Impact of COVID-19 on the State of Clinical and Laboratory Research Globally in Transplantation in May 2020
6/17/2020Journal:
Transplantation. 2020 Nov;104(11):2252-2257.Authors :
Jonathan Bromberg Carla Baan Jeremy Chapman Ignacio Anegon Daniel C Brennan Aron Chakera Anita S Chong Edward K Geissler Carole Guillonneau Nigel Heaton Dennis A Hesselink Wayel Jassem Christopher M Jones Regis Josien Bruce Kaplan Christina L Kaufman Wai Lim Yun Ma Emma Massey Darin B Ostrander Mark S Slaughter Stefan Tullius Piotr Witkowski Germaine WongNo abstract
