Liping Yu, MD

A Simple Multiplex Assay to Screening Multiple Autoimmune Diseases Simultaneously in Children 

This project aims to address the challenges of screening for multiple autoimmune diseases, such as Type 1 diabetes, celiac disease, and autoimmune thyroid disease, which affect millions of people. Existing screening methods are expensive and logistically difficult, with limited predictive value for Type 1 diabetes. The proposed solution is a novel multiplex assay that combines multiple autoantibodies for these diseases into one well, providing higher throughput, lower sample volume requirements, and lower cost compared to current methods. The project seeks to optimize and validate this assay to make it feasible for mass screening of the general population, screening for comorbidities among patients with autoimmune diseases, and diagnosing Type 1 diabetes accurately. Collaborators: Marian Rewers, MD, PhD, Aaron Michels, MD and Jia Xiaofan 

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